Piecing It All Together: Completing the Patient Recruitment Puzzle

What this means

Key takeaways from the report

Protocol complexity is increasing

Clinical teams need earlier visibility into feasibility risks, endpoint choices, eligibility criteria, and recruitment assumptions.

Protocol complexity is increasing

Clinical teams need earlier visibility into feasibility risks, endpoint choices, eligibility criteria, and recruitment assumptions.

Protocol complexity is increasing

Clinical teams need earlier visibility into feasibility risks, endpoint choices, eligibility criteria, and recruitment assumptions.

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Frequently Asked Questions

Why are traditional patient recruitment methods often insufficient for today's clinical trials?

Traditional, volume-based tactics — site database outreach, direct-to-patient advertising (TV, radio, print, online, and social media), and community events like health fairs — can work for chronic conditions, but they often produce significant drop-offs and screen failures, especially for trials with complex protocols.

What is the "third generation" of patient recruitment, and how does it differ from traditional approaches?

The third generation of patient recruitment replaces assumption-based planning with data-linked patient identification at population scale. Instead of relying on manual screening and limited site visibility, it uses multidimensional aggregation of proprietary and real-world data (RWD), along with tokenization technology, to surface patient populations that traditional site databases cannot reach.

Why does physician engagement matter?

Trust in physicians as a source of health information remains very high (90% in an April 2025 Annenberg Public Policy Center survey), and 51% of respondents in CISCRP’s 2025 Perceptions & Insights study prefer to hear about clinical research from their doctor — yet only 8% of those aware of a study actually heard about it that way.

Explore related solutions

Products behind the insights

Citeline PatientMatch

Empower investigators to consider every potential participant for your trial by alerting your site staff or CRO that a prospective clinical trial candidate presented at their site

Citeline Connect

The end-to-end solution to find, educate, engage, and enroll clinical trial participants worldwide

Trial Portfolio Websites

The comprehensive solution for educating, engaging and enrolling participants across an entire clinical trial portfolio

Explore further resources

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