Protocol SmartDesign combines AI-powered recommendations, trial performance data, and enrollment forecasting to help teams deliver successful clinical trials.
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Endpoints and I/E criteria informed by historically successful trials.
Enrollment rate and study duration forecast from trials most like yours, not a blanket average.
Every recommendation carries its source trials, viewable directly inside Trialtrove for review.
Get endpoints and criteria ranked by what has proven successful in past trials, a starting point you refine with your own clinical expertise.
See the enrollment rate and study duration your criteria produce, before you lock them in.
Every recommendation is backed by transparent evidence that medical and clinical operations teams can review together.
Recommendations draw on Trialtrove, built from 58K+ unique sources across 310+ diseases and 9 therapeutic areas, maintained by analysts with specialist focus areas.
Grounded in Citeline's curated trial, endpoint, and criteria data rather than scattered literature review.
A model built for protocol design with subject-matter experts, not a repurposed general-purpose tool.
Trace any recommendation to the trials behind it, viewable directly in Trialtrove. No black-box output.
AI-generated recommendations are a starting point. You refine every endpoint and criterion with your own clinical expertise.
Analysts with specialist focus areas maintain data quality, backed by 20+ years of clinical intelligence.
Carry protocol criteria into Cohort SmartBuilder and Investigator SmartSelect across the SmartSolutions workflow.
Recommended primary endpoints and I/E criteria arrive ranked by prevalence in trials that completed on schedule, sorted into expert-built categories, and open to edit with your own clinical expertise.
Median sites, median participants, and forecasted enrollment rate and study duration sit alongside every recommendation, and update automatically as you refine your criteria.
Every recommendation links to its source trials, with sponsor and timeframe, viewable directly in Trialtrove, including trials that were not operationally successful.
| Capabilities | Traditional protocol design | Protocol SmartDesign |
|---|---|---|
| Review protocol approaches from similar trials | ||
| Review source trials supporting design decisions | ||
| Endpoints and criteria informed by historically successful trials | ||
| Enrollment rate forecast for your exact criteria | ||
| Study duration forecast that updates as you edit | ||
| Recommendations linked directly to supporting trials | ||
| Unsuccessful trials shown alongside successful ones |
Turn your patient cohort into a ranked shortlist of sites and investigators.
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