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Design protocols real patients can qualify for and complete.

Validate I/E criteria against real populations, benchmark every protocol choice against 60,000+ curated trials, and cut the amendments that slow recruitment before they happen.

The Citeline Clinical Intelligence Platform
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Part of a connected clinical intelligence platform

Trial Design draws on the same analyst-curated data core as Clinical Landscape, Site Selection, and Patient Recruitment — so intelligence built during design carries forward without re-buying or re-entering data.

Clinical Landscape

See which therapies are advancing, for which populations.

Trial Design

Design protocols real patients can qualify for and complete.

Site Selection

Place trials where eligible patients and capable sites converge.

Patient Recruitment

Reach the right patients at the right moment.

Trusted data. Powerful analytics. Faster answers.

Built for better protocol planning

Trialtrove and its companion products bring together the industry's most comprehensive clinical trial dataset, advanced analytics, and AI-assisted workflows — helping teams move faster and plan with greater certainty.

Protocol design & optimization

AI-assisted protocol recommendations grounded in Trialtrove enrollment benchmarks — every endpoint, arm, and visit schedule stress-tested against what actually performed.

Competitive & endpoint benchmarking

Benchmark your trial against comparable studies — competitive trial and endpoint data, plus regulatory milestone and approval history, all in one place.

Real-time I/E criteria validation

Test inclusion and exclusion criteria against real-world data before protocol lock — see exactly how each rule shrinks or widens your eligible patient pool.

Trial Design in practice

What you can do with Trial Design

Eligibility-criteria modeling

Validate I/E criteria against real populations

Test every inclusion and exclusion rule against real-world data before the protocol is locked. See instantly how each criterion widens or narrows your eligible pool — and catch over-restriction before it reaches a site.

  • Real-time I/E validation against RWD
  • Patient pool sizing as criteria change
  • Patient density check at recommended sites
See what powers this ↓
Protocol design & optimization

AI-assisted protocol recommendations

Every protocol choice benchmarked against 60K+ curated trials. Trialtrove enrollment actuals, competitive trial and endpoint data, and regulatory history — all surfaced at the point of design.

  • AI-assisted protocol recommendations
  • Competitive trial and endpoint benchmarking
  • Regulatory milestone and approval history
See what powers this ↓
Competitive context

Benchmark against the live competitive landscape

See how comparable trials enrolled, where they stalled, and what the pipeline looks like for your indication — so design decisions are grounded in what the market is actually doing.

  • Enrollment performance actuals by indication
  • Trial Health Calculator scoring
  • Integrated pipeline and trial intelligence
See what powers this ↓

The data behind every design decision

60K+

Curated trials

With analyst-validated enrollment actuals

40%+

Faster curation

AI-accelerated, expert-validated data

95%+

Validated accuracy

Across all Citeline records

60%

Enrollment uplift

Reported improvement in trial enrollment

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